Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Acta2  actin alpha 2, smooth muscle, aorta   (Synonyms: 0610041G09Rik, Actvs, alphaSMA, a-SMA, SMAalpha, SMalphaA)
Results	Reference
1	J:86450 Allende ML, Yamashita T, Proia RL, G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation. Blood. 2003 Nov 15;102(10):3665-7
1	J:239479 Arora H, Boulberdaa M, Qureshi R, Bitirim V, Messadeq N, Dolle P, Nebigil CG, Prokineticin receptor 1 is required for mesenchymal-epithelial transition in kidney development. FASEB J. 2016 Aug;30(8):2733-40
1	J:171088 Barnes RM, Firulli BA, Vandusen NJ, Morikawa Y, Conway SJ, Cserjesi P, Vincentz JW, Firulli AB, Hand2 Loss-of-Function in Hand1-Expressing Cells Reveals Distinct Roles in Epicardial and Coronary Vessel Development. Circ Res. 2011 Apr 15;108(8):940-9
1	J:307822 Beal R, Alonso-Carriazo Fernandez A, Grammatopoulos DK, Matter K, Balda MS, ARHGEF18/p114RhoGEF Coordinates PKA/CREB Signaling and Actomyosin Remodeling to Promote Trophoblast Cell-Cell Fusion During Placenta Morphogenesis. Front Cell Dev Biol. 2021;9:658006
1	J:199581 Bohnenpoll T, Bettenhausen E, Weiss AC, Foik AB, Trowe MO, Blank P, Airik R, Kispert A, Tbx18 expression demarcates multipotent precursor populations in the developing urogenital system but is exclusively required within the ureteric mesenchymal lineage to suppress a renal stromal fate. Dev Biol. 2013 Aug 1;380(1):25-36
1	J:198769 Burstyn-Cohen T, Heeb MJ, Lemke G, Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis. J Clin Invest. 2009 Oct;119(10):2942-53
1	J:172032 Cain JE, Islam E, Haxho F, Blake J, Rosenblum ND, GLI3 repressor controls functional development of the mouse ureter. J Clin Invest. 2011 Mar 1;121(3):1199-206
1	J:163845 Chandana EP, Maeda Y, Ueda A, Kiyonari H, Oshima N, Yamamoto M, Kondo S, Oh J, Takahashi R, Yoshida Y, Kawashima S, Alexander DB, Kitayama H, Takahashi C, Tabata Y, Matsuzaki T, Noda M, Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice. BMC Dev Biol. 2010;10:84
1	J:135052 Cohen TV, Kosti O, Stewart CL, The nuclear envelope protein MAN1 regulates TGFbeta signaling and vasculogenesis in the embryonic yolk sac. Development. 2007 Apr;134(7):1385-95
1	J:273460 Collins TN, Mao Y, Li H, Bouaziz M, Hong A, Feng GS, Wang F, Quilliam LA, Chen L, Park T, Curran T, Zhang X, Crk proteins transduce FGF signaling to promote lens fiber cell elongation. Elife. 2018 Jan 23;7:e32586
1	J:174085 Cunningham K, Uchida Y, O'Donnell E, Claudio E, Li W, Soneji K, Wang H, Mukouyama YS, Siebenlist U, Conditional deletion of Ccm2 causes hemorrhage in the adult brain: a mouse model of human cerebral cavernous malformations. Hum Mol Genet. 2011 Aug 15;20(16):3198-206
1	J:139168 Dakubo GD, Mazerolle C, Furimsky M, Yu C, St-Jacques B, McMahon AP, Wallace VA, Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye. Dev Biol. 2008 Aug 1;320(1):242-55
1	J:330505 Drake KA, Chaney C, Patel M, Das A, Bittencourt J, Cohn M, Carroll TJ, Transcription Factors YAP/TAZ and SRF Cooperate To Specify Renal Myofibroblasts in the Developing Mouse Kidney. J Am Soc Nephrol. 2022 Aug 2;
1	J:189010 Gaengel K, Niaudet C, Hagikura K, Siemsen BL, Muhl L, Hofmann JJ, Ebarasi L, Nystrom S, Rymo S, Chen LL, Pang MF, Jin Y, Raschperger E, Roswall P, Schulte D, Benedito R, Larsson J, Hellstrom M, Fuxe J, Uhlen P, Adams R, Jakobsson L, Majumdar A, VestweberD, Uv A, Betsholtz C, The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2. Dev Cell. 2012 Sep 11;23(3):587-99
1*	J:260471 Gerhardt B, Leesman L, Burra K, Snowball J, Rosenzweig R, Guzman N, Ambalavanan M, Sinner D, Notum attenuates Wnt/beta-catenin signaling to promote tracheal cartilage patterning. Dev Biol. 2018 Apr 1;436(1):14-27
1	J:91658 Gitler AD, Lu MM, Epstein JA, PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Dev Cell. 2004 Jul;7(1):107-16
1	J:136180 Gontan C, de Munck A, Vermeij M, Grosveld F, Tibboel D, Rottier R, Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation. Dev Biol. 2008 May 1;317(1):296-309
1	J:345606 Gonzalez Galofre ZN, Kilpatrick AM, Marques M, Sa da Bandeira D, Ventura T, Gomez Salazar M, Bouilleau L, Marc Y, Barbosa AB, Rossi F, Beltran M, van de Werken HJG, van IJcken WFJ, Henderson NC, Forbes SJ, Crisan M, Runx1+ vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivo. Nat Commun. 2024 Feb 23;15(1):1653
1	J:90281 Greenberg JM, Thompson FY, Brooks SK, Shannon JM, Akeson AL, Slit and robo expression in the developing mouse lung. Dev Dyn. 2004 Jun;230(2):350-60
1	J:139642 Hou Y, Li F, Karin M, Ostrowski MC, Analysis of the IKKbeta/NF-kappaB signaling pathway during embryonic angiogenesis. Dev Dyn. 2008 Sep 24;237(10):2926-2935
1	J:144603 Kerkela R, Kockeritz L, Macaulay K, Zhou J, Doble BW, Beahm C, Greytak S, Woulfe K, Trivedi CM, Woodgett JR, Epstein JA, Force T, Huggins GS, Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation. J Clin Invest. 2008 Nov;118(11):3609-18
1	J:180905 Kim TH, Kim BM, Mao J, Rowan S, Shivdasani RA, Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme. Development. 2011 Aug;138(15):3225-33
1	J:138261 Kokubu H, Ohtsuka T, Kageyama R, Mash1 is required for neuroendocrine cell development in the glandular stomach. Genes Cells. 2008 Jan;13(1):41-51
1	J:130369 Koo BK, Yoon MJ, Yoon KJ, Im SK, Kim YY, Kim CH, Suh PG, Jan YN, Kong YY, An obligatory role of mind bomb-1 in notch signaling of Mammalian development. PLoS One. 2007;2(11):e1221
1	J:62182 Lai KM, Pawson T, The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo. Genes Dev. 2000 May 1;14(9):1132-45
1	J:50064 Lindahl P, Hellstrom M, Kalen M, Karlsson L, Pekny M, Pekna M, Soriano P, Betsholtz C, Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli. Development. 1998 Sep;125(17):3313-22
1	J:126240 Lu X, Le Noble F, Yuan L, Jiang Q, De Lafarge B, Sugiyama D, Breant C, Claes F, De Smet F, Thomas JL, Autiero M, Carmeliet P, Tessier-Lavigne M, Eichmann A, The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature. 2004 Nov 11;432(7014):179-86
1	J:200735 Mao X, Debenedittis P, Sun Y, Chen J, Yuan K, Jiao K, Chen Y, Vascular smooth muscle cell Smad4 gene is important for mouse vascular development. Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2171-7
1	J:102822 Molin DG, DeRuiter MC, Wisse LJ, Azhar M, Doetschman T, Poelmann RE, Gittenberger-de Groot AC, Altered apoptosis pattern during pharyngeal arch artery remodelling is associated with aortic arch malformations in Tgfbeta2 knock-out mice. Cardiovasc Res. 2002 Nov;56(2):312-22
1	J:83133 Nemer G, Nemer M, Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6. Dev Biol. 2003 Feb 1;254(1):131-48
1	J:171374 Osorio KM, Lilja KC, Tumbar T, Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments. J Cell Biol. 2011 Apr 4;193(1):235-50
1	J:236785 Pathania M, Wang Y, Simirskii VN, Duncan MK, beta1-integrin controls cell fate specification in early lens development. Differentiation. 2016 Oct - Nov;92(4):133-147
1	J:54469 Pereira FA, Qiu Y, Zhou G, Tsai MJ, Tsai SY, The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development. Genes Dev. 1999 Apr 15;13(8):1037-49
1	J:138768 Screen M, Dean W, Cross JC, Hemberger M, Cathepsin proteases have distinct roles in trophoblast function and vascular remodelling. Development. 2008 Oct;135(19):3311-20
1	J:314577 Shao X, Liu K, Fan Y, Ding Z, Chen M, Zhu M, Weinstein LS, Li H, Li H, Galphas Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity. J Genet Genomics. 2015 Nov 20;42(11):613-624
1	J:187683 Shoham AB, Malkinson G, Krief S, Shwartz Y, Ely Y, Ferrara N, Yaniv K, Zelzer E, S1P1 inhibits sprouting angiogenesis during vascular development. Development. 2012 Oct;139(20):3859-69
1	J:82356 Takahashi T, Takahashi K, St John PL, Fleming PA, Tomemori T, Watanabe T, Abrahamson DR, Drake CJ, Shirasawa T, Daniel TO, A mutant receptor tyrosine phosphatase, CD148, causes defects in vascular development. Mol Cell Biol. 2003 Mar;23(5):1817-31
1	J:225175 Turcatel G, Rubin N, Menke DB, Martin G, Shi W, Warburton D, Lung mesenchymal expression of Sox9 plays a critical role in tracheal development. BMC Biol. 2013;11:117
1	J:69406 Uyttendaele H, Ho J, Rossant J, Kitajewski J, Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium. Proc Natl Acad Sci U S A. 2001 May 8;98(10):5643-8
1	J:279272 Wang JJ, Liu HX, Song L, Li HR, Yang YP, Zhang T, Jing Y, Isl-1 positive pharyngeal mesenchyme subpopulation and its role in the separation and remodeling of the aortic sac in embryonic mouse heart. Dev Dyn. 2019 Sep;248(9):771-783
1	J:240021 Wang X, Astrof S, Neural crest cell-autonomous roles of fibronectin in cardiovascular development. Development. 2016 Jan 01;143(1):88-100
1	J:141490 Welser JV, Lange ND, Flintoff-Dye N, Burkin HR, Burkin DJ, Placental defects in alpha7 integrin null mice. Placenta. 2007 Nov-Dec;28(11-12):1219-28
1	J:340740 Xu J, Zhou X, Zhang T, Zhang B, Xu PX, Smarca4 deficiency induces Pttg1 oncogene upregulation and hyperproliferation of tubular and interstitial cells during kidney development. Front Cell Dev Biol. 2023;11:1233317
1	J:117242 Yokomizo T, Takahashi S, Mochizuki N, Kuroha T, Ema M, Wakamatsu A, Shimizu R, Ohneda O, Osato M, Okada H, Komori T, Ogawa M, Nishikawa S, Ito Y, Yamamoto M, Characterization of GATA-1(+) hemangioblastic cells in the mouse embryo. EMBO J. 2007 Jan 10;26(1):184-96
1	J:98247 You LR, Lin FJ, Lee CT, DeMayo FJ, Tsai MJ, Tsai SY, Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity. Nature. 2005 May 5;435(7038):98-104
1	J:164023 Zhang C, Tian L, Chi C, Wu X, Yang X, Han M, Xu T, Zhuang Y, Deng K, Adam10 is essential for early embryonic cardiovascular development. Dev Dyn. 2010 Oct;239(10):2594-602
1	J:157920 Zovein AC, Luque A, Turlo KA, Hofmann JJ, Yee KM, Becker MS, Fassler R, Mellman I, Lane TF, Iruela-Arispe ML, Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism. Dev Cell. 2010 Jan 19;18(1):39-51